乳酸在赖氨酸752位点触发KAT8介导的LTBP1乳酸化，通过诱导成纤维细胞中的胶原蛋白合成来促进皮肤年轻化

邹颖a, b, 1，曹米布a, 1，陶丽b, 1，伍姝b，周浩贤c，张有良a，陈义庆a，葛远龙b, *，鞠振宇a, b, **，罗盛康a, b, **

成纤维细胞胶原蛋白合成减少是皮肤衰老的关键环节。聚L‑乳酸（PLLA）是一种可生物吸收材料，能够持续释放乳酸，刺激皮肤内源性胶原蛋白的合成。

Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by induc

Ying Zou a,b,1 , Mibu Cao a,1 , Li Tao b,1 , Shu Wu b , Haoxian Zhou c , Youliang Zhang a , Yiqing Chen a , Yuanlong Ge b,* , Zhenyu Ju a,b,**, Shengkang Luo a,b,

Decreased collagen synthesis by fibroblasts is a key aspect of skin aging. Poly-L-Lactic Acid (PLLA) is a bioabsorbable material that can release lactate continuously, stimulating endogenous collagen synthesis in the skin.Herein, this study aimed to inv

聚-L-乳酸微球真皮填充剂在体内刺激胶原合成的有效性

于昊，张有良，陈尹，董云先，洪伟晋，罗盛康,

In Vivo Effectiveness of Poly-L-Lactic Acid Microsphere Dermal Fillers in Stimulating Collagen Synth

Hao Yu1 • You-liang Zhang1 • Yin Chen2 • Yun-xian Dong1 • Wei-jin Hong1 • Sheng-kang Luo1

Background Intradermal injections of fillers such as polyL-lactic acid (PLLA) microspheres and hyaluronic acid(HA) offer the possibility of skin rejuvenation. However,the biological effects of these fillers and the mechanisms underlying collagen synthes