通过微聚焦超声（MFU）增强聚左旋乳酸（PLLA）注射疗效：联合治疗效果及最佳治疗顺序的评估

金长鑫1，李丹2, 3，詹威2，王世旭2, 4，李高旭2, 4，李瑞雪2, 4，王一杰2, 4

聚左旋乳酸（poly-L-lactic acid，PLLA）与微聚焦超声（micro-focused ultrasound，MFU）均被广泛应用于皮肤年轻化治疗，两者通过不同的作用机制促进胶原重塑。尽管在临床实践中联合应用较为常见，但其最佳治疗顺序及安全性特征仍缺乏明确证据。本研究旨在通过临床前模型评估PLLA与MFU联合治疗的协同效应及理想治疗顺序，为临床方案制定提供依据。

Enhancing the Efficacy of Poly-l-Lactic Acid Injections With Micro-Focused Ultrasound: An Evaluatio

Changxin Jin1 | Dan Li2,3 | Wei Zhan2 | Shixu Wang2,4 | Gaoxu Li2,4 | Ruixue Li2,4 | Yijie Wang2,4 | Bo Zhou2,4 | Fulin Chen4 | Qiong Wu2,4

Introduction: Poly-l-lactic acid (PLLA) and micro-focused ultrasound (MFU) are widely used for skin rejuvenation, each promoting collagen remodeling through distinct mechanisms. While combined use is common in practice, the optimal treatment sequence

聚左旋乳酸通过其代谢产物乳酸减少真皮脂肪组织体积

金雯 4, 陈刚 5, 陈威 1, 乔冠群1, 邓乐曲 1, 李锴 2,3, ✉, 蔡薇1, ✉

聚左旋乳酸（Poly-L-lactic acid, PLLA）是一种成熟的生物刺激剂，可通过诱导胶原酶生成广泛应用于临床皮肤抗衰老治疗。然而，PLLA对成纤维细胞之外其他真皮细胞亚群的精确调控机制尚未完全阐明。

Poly-L-Lactic Acid Reduces the Volume of Dermal Adipose Tissue Through its Metabolite Lactate

Wen Jin4 • Gang Chen5 • Wei Chen1 • Guanqun Qiao1 • Yuequ Deng1 • Kai Li2,3 • Wei Cai1

Poly-L-lactic acid (PLLA), a well-established biostimulator that induces collagenases, is widely used among clinical practice to treat skin aging.